中文名称:兔抗ARNT多克隆抗体
英文名称:Anti-ARNT rabbit polyclonal antibody别 名:ARNT; HIF-1beta; HIF1B; HIF1BETA; TANGO; bHLHe2
相关类别:一抗
储 存:冷冻(-20℃) 避光
宿 主:Rabbit
抗 原:ARNT
反应种属:Human, Mouse, Rat
标 记 物:Unconjugate
克隆类型:rabbit polyclonal
技术规格
Background:
Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor that plays a critical role in the cellular response to hypoxia. The HIF1 complex consists of two subunits, HIF-1α and HIF-1β, which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. HIF1 regulates the transcription of a broad range of genes that facilitate responses to the hypoxic environment, including genes regulating angiogenesis, erythropoiesis, cell cycle, metabolism and apoptosis. The widely expressed HIF-1α is typically degraded rapidly in normoxic cells by the ubiquitin/proteasomal pathway. Under normoxic conditions, HIF-1α is proline hydroxylated leading to a conformational change that promotes binding to the von Hippel Lindau protein (VLH) E3 ligase complex; ubiquitination and proteasomal degradation follows. Both hypoxic conditions and chemical hydroxylase inhibitors (such as desferrioxamine and cobalt) inhibit HIF-1α degradation and lead to its stabilization. In addition, HIF-1α can be induced in an oxygen-independent manner by various cytokines through the PI3K-AKT-mTOR pathway.HIF-1β is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex. Together with AhR, HIF-1β plays an important role in xenobiotics metabolism. In addition, a chromosomal translocation leading to a TEL-ARNT fusion protein is associated with acute myeloblastic leukemia. Studies also found that ARNT/HIF-1β expression levels decrease significantly in pancreatic islets from patients with type 2 diabetes, suggesting that HIF-1β plays an important role in pancreatic β-cell function.
Applications:
WB
Name of antibody:
ARNT
Immunogen:
Fusion protein of human ARNT
Full name:
aryl hydrocarbon receptor nuclear translocator
Synonyms:
ARNT; HIF-1beta; HIF1B; HIF1BETA; TANGO; bHLHe2
SwissProt:
P27540
WB Predicted band size:
87 kDa
WB Positive control:
Hepg2, MCF7, NIH3T3, U20S and Hela cells
WB Recommended dilution:
500-2000
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