中文名称:兔抗CCAR2多克隆抗体
英文名称:Anti-CCAR2 rabbit polyclonal antibody
别 名:cell cycle and apoptosis regulator 2; DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967相关类别:一抗
储 存:冷冻(-20℃)
宿 主:Rabbit
抗 原:CCAR2
反应种属:Human, Mouse
标 记 物:Unconjugate
克隆类型:rabbit polyclonal
技术规格
Background:
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978).
Applications:
ELISA, IHC
Name of antibody:
CCAR2
Immunogen:
Synthetic peptide of human CCAR2
Full name:
cell cycle and apoptosis regulator 2
Synonyms:
DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967
SwissProt:
Q8N163
ELISA Recommended dilution:
5000-10000
IHC positive control:
Human prostate cancer
IHC Recommend dilution:
50-100
产品标签
用户评论(共6条评论)
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