中文名称: 兔抗HLA-A/F/H多克隆抗体
英文名称: Anti-HLA-A/F/H rabbit polyclonal antibody
别 名: major histocompatibility complex, class I, A/F/H; HLAA; HLAF; CDA12; HLA-5.4; HLA-CDA12; HLAHP
抗 原: HLA-A/F/H
储 存: 冷冻(-20℃)
宿 主: Rabbit
反应种属: Human
相关类别: 一抗
标 记 物: Unconjugate
克隆类型: rabbit polyclonal
技术规格
Background:
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. HLA-F belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. HLA-H represents a transcribed pseudogene, possibly derived from HLA-A. This gene displays extensive variation.
Applications:
ELISA, IHC
Name of antibody:
HLA-A/F/H
Immunogen:
Synthetic peptide of human HLA-A/F/H
Full name:
major histocompatibility complex, class I, A/F/H
Synonyms:
HLAA; HLAF; CDA12; HLA-5.4; HLA-CDA12; HLAHP
SwissProt:
P01893
ELISA Recommended dilution:
5000-10000
IHC positive control:
Human tonsil and Human cervical cancer
IHC Recommend dilution:
25-100
产品标签
用户评论(共6条评论)
- 膜粘连蛋白11抗体
- 乙醛脱氢酶2型抗体
- 锚定蛋白重复结构域蛋白激酶ANKK1抗体
- 载脂蛋白B-mRNA编辑酶复合物1抗体
- 膜粘连蛋白13抗体
- Rho GTP酶激活蛋白15抗体
- 遗传性失明相关蛋白AIPL1抗体
- 真核翻译起始因子2C4抗体
- 抑癌基因结合蛋白ARID1B抗体
- 肌动蛋白相关蛋白M1抗体
- 载脂蛋白B-mRNA编辑酶复合物3B抗体
- 真核翻译起始因子2C3抗体
- 釉基质蛋白抗体
- 肌动蛋白结合蛋白LIM蛋白3抗体
- 细胞周期后期促进蛋白亚基10抗体
- 脂肪细胞膜相关蛋白抗体
- ADP核糖基化因子5抗体
- 肌动蛋白相关蛋白2/3亚型2抗体
- 载脂蛋白M抗体
- 磷酸化CD156b抗体
- 载脂蛋白L1抗体
- ADP核糖基化因子1抗体
- 载脂蛋白O抗体
- 乙醇脱氢酶6抗体
- 细胞周期后期促进蛋白亚基11抗体
- 载脂蛋白B-mRNA编辑酶复合物3C抗体
- DNA修复酶相互作用蛋白抗体
- ADP核糖基化因子相关蛋白1
- ADP核糖基化因子样蛋白4抗体
- 载脂蛋白A1结合蛋白抗体抗体
- 载脂蛋白C1抗体
- γ-氨基丁酸醛脱氢酶抗体
- 精氨酰tRNA合成酶抗体
- ADP核糖基化因子GTP酶激活蛋白1抗体
- ATP结合蛋白家族7抗体
- 腺嘌呤磷酸核糖转移酶抗体
- 肌动蛋白相关蛋白2/3抗体
- 氨肽酶A抗体
- 载脂蛋白B-mRNA编辑酶复合物2抗体
- ASCL2蛋白抗体
- 乙醇脱氢酶5抗体
- 腺瘤性结肠息肉病蛋白2抗体
- β淀粉样蛋白前体蛋白结合蛋白1抗体
- 毛细血管扩张性共济失调症突变蛋白抗体
- ADP核糖基化样因子1抗体
- 转录因子AP2α+β抗体
- 磷酸化腺瘤样息肉抗体
- ADP核糖基化因子结合蛋白抗体
- E3连接酶蛋白ARIH2抗体
- 载脂蛋白L5抗体
- 免疫调节蛋白AIRE抗体
- 乙醛脱氢酶家族3成员A1抗体
- γ2肌动蛋白抗体
- 衰老相关蛋白5抗体
- 载脂蛋白L4抗体
- 肌动蛋白相关蛋白2/3亚型4抗体
- 磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体
- 琥珀酸裂解酶抗体
- 共济失调性眼球运动功能丧失相关蛋白AOA1抗体
- ATP结合盒转运蛋白2抗体
上海酶联生物科技有限公司
Shanghai Enzyme-linked Biotechnology Co., Ltd.
订购热线:4008-898-798 / 021-54720761
传 真:021-54222852
地址:上海市松江区云凯路66号T2楼1603室
酶联官方手机二维码
微信扫描二维码,参与酶联活动,
劲爆优惠触手可得!
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或治疗,非药用,非食用。