中文名称: 兔抗NFKB1 (Phospho-Ser337)多克隆抗体
英文名称: Anti-NFKB1 (Phospho-Ser337) rabbit polyclonal antibody
别 名: p50; KBF1; p105; EBP-1; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B
相关类别: 一抗
储 存: 冷冻(-20℃) 避光
宿 主: Rabbit
抗 原: NFKB1 (Phospho-Ser337)
反应种属: Human, Mouse, Rat
标 记 物: Unconjugate
克隆类型:rabbit polyclonal
技术规格
Background:
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.
Applications:
WB, IHC, IF
Name of antibody:
NFKB1 (Phospho-Ser337)
Immunogen:
Synthetic peptide of human NFKB1 (Phospho-Ser337)
Full name:
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (Phospho-Ser337)
Synonyms:
p50; KBF1; p105; EBP-1; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B
SwissProt:
P19838
IHC positive control:
Human breast carcinoma
IHC Recommend dilution:
50-100
WB Predicted band size:
50 kDa; 120 kDa
WB Positive control:
HeLa cells
WB Recommended dilution:
500-1000
IF Positive control:
HeLa cells
IF Recommended dilution
100-200
产品标签
用户评论(共6条评论)
- 载脂蛋白B-mRNA编辑酶复合物1抗体
- 细胞周期后期促进蛋白亚基11抗体
- 载脂蛋白O抗体
- 毛细血管扩张性共济失调症突变蛋白抗体
- ADP核糖基化因子相关蛋白1
- 载脂蛋白L4抗体
- 琥珀酸裂解酶抗体
- 腺瘤性结肠息肉病蛋白2抗体
- γ2肌动蛋白抗体
- β淀粉样蛋白前体蛋白结合蛋白1抗体
- 乙醛脱氢酶2型抗体
- 膜粘连蛋白11抗体
- 肌动蛋白结合蛋白LIM蛋白3抗体
- 磷酸化CD156b抗体
- 氨肽酶A抗体
- ADP核糖基化样因子1抗体
- 脂肪细胞膜相关蛋白抗体
- ADP核糖基化因子5抗体
- 免疫调节蛋白AIRE抗体
- 肌动蛋白相关蛋白M1抗体
- 乙醇脱氢酶5抗体
- Rho GTP酶激活蛋白15抗体
- ADP核糖基化因子样蛋白4抗体
- ADP核糖基化因子结合蛋白抗体
- ATP结合蛋白家族7抗体
- 载脂蛋白A1结合蛋白抗体抗体
- ATP结合盒转运蛋白2抗体
- 载脂蛋白C1抗体
- 肌动蛋白相关蛋白2/3亚型2抗体
- 釉基质蛋白抗体
- 乙醛脱氢酶家族3成员A1抗体
- 锚定蛋白重复结构域蛋白激酶ANKK1抗体
- E3连接酶蛋白ARIH2抗体
- γ-氨基丁酸醛脱氢酶抗体
- 转录因子AP2α+β抗体
- 衰老相关蛋白5抗体
- 载脂蛋白B-mRNA编辑酶复合物3B抗体
- ADP核糖基化因子1抗体
- 精氨酰tRNA合成酶抗体
- 遗传性失明相关蛋白AIPL1抗体
- 载脂蛋白L5抗体
- 载脂蛋白L1抗体
- 膜粘连蛋白13抗体
- 乙醇脱氢酶6抗体
- ADP核糖基化因子GTP酶激活蛋白1抗体
- 肌动蛋白相关蛋白2/3抗体
- 载脂蛋白B-mRNA编辑酶复合物3C抗体
- 载脂蛋白M抗体
- 磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体
- 真核翻译起始因子2C3抗体
- 腺嘌呤磷酸核糖转移酶抗体
- DNA修复酶相互作用蛋白抗体
- 抑癌基因结合蛋白ARID1B抗体
- 载脂蛋白B-mRNA编辑酶复合物2抗体
- 真核翻译起始因子2C4抗体
- 细胞周期后期促进蛋白亚基10抗体
- ASCL2蛋白抗体
- 磷酸化腺瘤样息肉抗体
- 共济失调性眼球运动功能丧失相关蛋白AOA1抗体
- 肌动蛋白相关蛋白2/3亚型4抗体
上海酶联生物科技有限公司
Shanghai Enzyme-linked Biotechnology Co., Ltd.
订购热线:4008-898-798 / 021-54720761
传 真:021-54222852
地址:上海市松江区云凯路66号T2楼1603室
酶联官方手机二维码
微信扫描二维码,参与酶联活动,
劲爆优惠触手可得!
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或治疗,非药用,非食用。