中文名称: CALR抗原(重组蛋白)
英文名称:CALR Antigen (Recombinant Protein)
储 存:冷冻(-20℃)
相关类别:抗原
概 述:Fusion protein corresponding to a region derived from 20-218 amino acids of human CALR技术规格:CALR抗原(重组蛋白)
Full name:
Calreticulin
Synonyms:
RO; CRT; SSA; cC1qR
Swissprot:
P27797
Gene Accession:
BC002500
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.
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