中文名称:CEACAM1抗原(重组蛋白)
英文名称:CEACAM1 Antigen (Recombinant Protein)
储 存:冷冻(-20℃)
相关类别:抗原
概 述:Fusion protein corresponding to a region derived from 145-413 amino acids of human CEACAM1技术规格:CEACAM1抗原(重组蛋白)
Full name:
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Synonyms:
BGP, BGP1, BGPI
Swissprot:
P13688
Gene Accession:
BC014473
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses.
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