中文名称: NELFA抗原(重组蛋白)
英文名称:NELFA Antigen (Recombinant Protein)
别 名:negative elongation factor complex member A; WHSC2; NELF-A; P/OKcl.15
相关类别:抗原
储 存:冷冻(-20℃)
概 述:
Fusion protein corresponding to a region derived from 329-528 amino acids of human NELFA技术规格:NELFA抗原(重组蛋白)
Full name:
negative elongation factor complex member A
Synonyms:
WHSC2; NELF-A; P/OKcl.15
Swissprot:
Q9H3P2
Gene Accession:
BC002764
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
产品标签
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