中文名称:RNF144B 抗原(重组蛋白)
英文名称:RNF144B Antigen (Recombinant Protein)
别 名:ring finger protein 144B; PIR2; IBRDC2; p53RFP; bA528A10.3
储 存:冷冻(-20℃)
相关类别:抗原
概 述Fusion protein corresponding to N terminal 250 amino acids of human RNF144B技术规格
Full name:
ring finger protein 144B
Synonyms:
PIR2; IBRDC2; p53RFP; bA528A10.3
Swissprot:
Q7Z419
Gene Accession:
BC063311
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle.
产品标签
用户评论(共6条评论)
- ARL8A抗原(重组蛋白)
- ASF1A抗原(重组蛋白)
- ANXA2抗原(重组蛋白)
- ACAD10抗原(重组蛋白)
- ASPA抗原(重组蛋白)
- ALKBH8抗原(重组蛋白)
- ABCC6抗原(重组蛋白)
- ACSBG2抗原(重组蛋白)
- ACY3抗原(重组蛋白)
- ANGPT1抗原(重组蛋白)
- ACBD4抗原(重组蛋白)
- ACTG1抗原(重组蛋白)
- ATG12抗原(重组蛋白)
- BOLL抗原(重组蛋白)
- ANP32A抗原(重组蛋白)
- AP2S1抗原(重组蛋白)
- ARHGDIA抗原(重组蛋白)
- AKR1B1抗原(重组蛋白)
- AKR1D1抗原(重组蛋白)
- ALKBH2抗原(重组蛋白)
- ACOT8抗原(重组蛋白)
- ADD1抗原(重组蛋白)
- ADAM17抗原(重组蛋白)
- ACVR1B抗原(重组蛋白)
- ADAP1抗原(重组蛋白)
- ARMC10抗原(重组蛋白)
- A4GALT 抗原(重组蛋白)
- ARF6抗原(重组蛋白)
- AKR1B10抗原(重组蛋白)
- APIP抗原(重组蛋白)
- AIF1抗原(重组蛋白)
- BID抗原(重组蛋白)
- AKAP9抗原(重组蛋白)
- ACP3抗原(重组蛋白)
- AURKAIP1抗原(重组蛋白)
- ATOX1抗原(重组蛋白)
- ANXA1抗原(重组蛋白)
- ARL11抗原(重组蛋白)
- ADAM7抗原(重组蛋白)
- ACMSD抗原(重组蛋白)
- B2M抗原(重组蛋白)
- ARF4抗原(重组蛋白)
- ARL6抗原(重组蛋白)
- ANKRD1抗原(重组蛋白)
- ATP6V1E2抗原(重组蛋白)
- ATP6V0D1抗原(重组蛋白)
- ANGPTL4抗原(重组蛋白)
- APOC1抗原(重组蛋白)
- ANAPC13抗原(重组蛋白)
- ATG5抗原(重组蛋白)
- AASDHPPT抗原(重组蛋白)
- ASB9抗原(重组蛋白)
- BIRC7抗原(重组蛋白)
- AGER抗原(重组蛋白)
- ANAPC10抗原(重组蛋白)
- ACOT2抗原(重组蛋白)
- ANXA10抗原(重组蛋白)
- BCL10抗原(重组蛋白)
- BCAS2抗原(重组蛋白)
- ARL2抗原(重组蛋白)
上海酶联生物科技有限公司
Shanghai Enzyme-linked Biotechnology Co., Ltd.
订购热线:4008-898-798 / 021-54720761
传 真:021-54222852
地址:上海市松江区云凯路66号T2楼1603室
酶联官方手机二维码
微信扫描二维码,参与酶联活动,
劲爆优惠触手可得!
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或治疗,非药用,非食用。